1. Wohlfromm F, Richter M, Otrin L, Seyrek K, Vidakovic-Koch T, Kuligina E, Richter V, Koval O, Lavrik IN. Interplay Between Mitophagy and Apoptosis Defines a Cell Fate Upon Co-treatment of Breast Cancer Cells With a Recombinant Fragment of Human Κ-Casein and Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand. Front. Cell Dev. Biol. 2021 Jan 18. doi: 10.3389/fcell.2020.617762
  1. Hillert LK, Ivanisenko NV, Busse D, Espe J, König C, Peltek SE, Kolchanov NA, Ivanisenko VA, Lavrik IN.Dissecting DISC regulation via pharmacological targeting of caspase-8/c-FLIPL heterodimer. Cell Death Differ. 2020 Jan 20. doi: 10.1038/s41418-020-0489-0
  2. Seyrek K, Ivanisenko NV, Richter M, Hillert LK, König C, Lavrik IN. Controlling Cell Death through Post-translational Modifications of DED Proteins. Trends Cell Biol. 2020 May 30. doi 10.1016/j.tcb2020.02.006
  3. Richter M, Wohlfromm F, Kähne T, Bongartz H, Seyrek K, Kit Y, Chinak O, Richter VA, Koval OA, Lavrik IN. The Recombinant Fragment of Human K-Casein Induces Cell Death by Targeting the Proteins of Mitochondrial Import in Breast Cancer Cells.Cancers. 2020 May 31. doi 10.3390/cancers12061427  
  4. Shah A, Plaza-Sirvent C, Weinert S, Buchbinder JH, Lavrik IN, Mertens PR, Schmitz I, Lindquist JA. YB-1 Mediates TNF-Induced Pro-Survival Signaling by Regulationg NF-KB Activation. Cancers. 2020 Aug. 5. doi: 10.3390/cancers12082188
  5. Ivanisenko NV, Seyrek K, Kolchanov NA, Ivanisenko VA, Lavrik IN. The role of death domain proteins in host response upon SARS-CoV-2 infection: modulation of programmed cell death and translational applications. Cell Death Discov. 2020.Oct.10. doi: 10.1038/s41420-020-00331-w
  6. Ivanisenko NV, Lavrik IN. Mathematical Modeling Reveals the Importance of the DED Filament Composition in the Effects of Small Molecules Targeting Caspase-8/c-FLIPL Heterodimer. Biochemistry. 2020. Oct. doi: 10.1134/S0006297920100028.
  7. König C, Hillert-Richter LK, Ivanisenko NV, Ivanisenko VA, Lavrik IN. Pharmacological targeting of c-FLIPL and Bcl-2 family members promotes apoptosis in CD95L-resistant cells. Sci Rep. 2020 Nov. 30. doi: 10.1038/s41598020-76079-1
  1. Hillert LK, Bettermann-Bethge K, Nimmagadda SC, Fischer T, Naumann M, Lavrik IN. Targeting RIPK1 in AML cells carrying FLT3-ITD. Int J Cancer. 145 (6): DOI 10.1002/ijc. 32246 Epub 2019 March.

  2. Hillert LK, Ivanisenko NV, Espe J, König C, Ivanisenko VA, Kähne T, Lavrik IN. Long and short isoforms of c-FLIP act as control checkpoints of DED filament assembly. Oncogene. 2019 Nov 18. doi: 10.1038/s41388-019-1100-3.

  3. Bagamanshina AV, Troitskaya OS, Nushtaeva AA, Yunusova AY, Starykovych MO, Kuligina EV, Kit YY, Richter M, Wohlfromm F, Kähne T, Lavrik IN, Richter VA, Koval OA. Cytotoxic and Antitumor Activity of Lactaptin in Combination with Autophagy Inducers and Inhibitors. Biomed Res Int. 2019 Jun 17;2019:4087160. doi: 10.1155/2019/4087160. eCollection 2019.

  4. Ivanisenko NV, Buchbinder JH, Espe J, Richter M, Bollmann M, Hillert LK, Ivanisenko VA, Lavrik IN. Delineating the role of c-FLIP/NEMO interaction in the CD95 network via rational design of molecular probes. BMC Genomics. 2019 May 8;20(Suppl 3):293. doi: 10.1186/s12864-019-5539-y.

  1. Pischel D, Buchbinder JH, Sundmacher K, Lavrik IN, Flassig RJ. A guide to automated apoptosis detection: How to make sense of imaging flow cytometry data. PLoS One. 13(5):  DOI: 10.1371/journal.pone.0197208. eCollection 2018.

  2. Buchbinder JH, Pischel D, Sundmacher K, Flassig RJ, Lavrik IN. Quantitative single cell analysis uncovers the life/death decision in CD95 network. PLoS Comput Biol.14(9): DOI 10.1371/journal.pcni.10006368. eCollection 2018 Sep.
  1. Pietkiewicz S, Wolfe C, Buchbinder JH and Lavrik IN. Measuring Procaspase-8 and -10 Processing upon Apoptosis Induction. Bio-protocol 7(1): e2081. DOI: 10.21769/BioProtoc.2081

  2. Zamaraev AV, Kopeina GS, Prokhorova EA, Zhivotovsky B, Lavrik IN. Post-translational Modification of Caspases: The Other Side of Apoptosis Regulation. Trends Cell Biol. 2017 May;27(5):322-339. doi: 10.1016/j.tcb.2017.01.003

  3. Lim MCC, Maubach G, Sokolova O, Feige MH, Diezko R, Buchbinder J, Backert S, Schlüter D, Lavrik IN, Naumann M. Pathogen-induced ubiquitin-editing enzyme A20 bifunctionally shuts off NF-κB and caspase-8-dependent apoptotic cell death. Cell Death Differ. 2017 Jun 2. doi: 10.1038/cdd.2017.89

  1. Möhle L, Israel N, Paarmann K, Krohn M, Pietkiewicz S, Müller A, Lavrik IN, Buguliskis JS, Schott BH, Schlüter D, Gundelfinger ED, Montag D, Seifert U, Pahnke J, Dunay IR. Chronic Toxoplasma gondii infection enhances β-amyloid phagocytosis and clearance by recruited monocytes. Acta Neuropathol Commun. 2016 Mar 16;4(1):25.

  2. Schleich K, Buchbinder JH, Pietkiewicz S, Kähne T, Warnken U, Öztürk S, Schnölzer M, Naumann M, Krammer PH, Lavrik IN. 2015. Molecular architecture of the DED chains at the DISC: regulation of procaspase-8 activation by short DED proteins c-FLIP and procaspase-8 prodomain. Cell Death Differ. 2016 Apr;23(4):681-94.

  3. Zimmer C, Schleich K, Lavrik I. Parameter identification using stochastic simulations reveals a robustness in CD95 apoptotic response. Mol Biosyst. 2016 Apr 26;12(5):1486-95

  4.  Just S, Nishanth G, Buchbinder JH, Wang X, Naumann M, Lavrik I, Schlüter D. A20 Curtails Primary but Augments Secondary CD8+ T Cell Responses in Intracellular Bacterial Infection. Sci Rep. 2016 Dec 22;6:39796.

  1. Popik OV, Petrovskiy ED, Mishchenko EL, Lavrik IN, Ivanisenko VA. 2015. Mosaic gene network modelling identified new regulatory mechanisms in HCV infection. Virus Res. 2015 Oct 22.

  2. Boehme JD, Pietkiewicz S, Lavrik I, Jeron A, Bruder D. 2015. Morphological and Functional Alterations of Alveolar Macrophages in a Murine Model of Chronic Inflammatory Lung Disease. Lung. 2015 Dec;193(6):947-953

  3. Pietkiewicz S, Eils R, Krammer PH, Giese N, Lavrik IN. 2015. Combinatorial treatment of CD95L and gemcitabine in pancreatic cancer cells induces apoptotic and RIP1-mediated necroptotic cell death network. Exp Cell Res. 2015 Oct 8.

  4. Prokhorova EA, Zamaraev AV, Kopeina GS, Zhivotovsky B, Lavrik IN. 2015. Role of the nucleus in apoptosis: signaling and execution. Cell Mol Life Sci. 2015 Dec;72(23):4593-612.

  5. Zamaraev AV, Kopeina GS, Zhivotovsky B, Lavrik IN. 2015. Cell death controlling complexes and their potential therapeutic role. Cell Mol Life Sci. 2015 Feb;72(3):505-17

  6. Pietkiewicz S, Schmidt JH, Lavrik IN. 2015. Quantification of apoptosis and necroptosis at the single cell level by a combination of Imaging Flow Cytometry with classical Annexin V/propidium iodide staining. J Immunol Methods. 2015 Aug;423:99-103

  7. Schmidt JH, Pietkiewicz S, Naumann M, Lavrik IN. 2015. Quantification of CD95-induced apoptosis and NF-κB activation at the single cell level. J Immunol Methods. 2015 Aug;423:12-7.

  8. Petrovskiy ED, Saik OV, Tiys ES, Lavrik IN, Kolchanov NA, Ivanisenko VA. 2015. Prediction of tissue-specific effects of gene knockout on apoptosis in different anatomical structures of human brain. BMC Genomics. 2015 Dec 16;16 Suppl 13:S3.

  1. Popik OV, Saik OV, Petrovskiy ED, Sommer B, Hofestädt R, Lavrik IN, Ivanisenko VA. 2014. Analysis of signaling networks distributed over intracellular compartments based on protein-protein interactions. BMC Genomics. 15 Suppl 12:S7

  2. Dieterle AM, Böhler P, Keppeler H, Alers S, Berleth N, Drießen S, Hieke N, Pietkiewicz S, Löffler AS, Peter C, Gray A, Leslie NR, Shinohara H, Kurosaki T, Engelke M, Wienands J, Bonin M, Wesselborg S, Stork B. 2014. PDK1 controls upstream PI3K expression and PIP3 generation. Oncogene. 5;33(23):3043-53

  3. Bettermann K, Hohensee T, Haybaeck J. 2014. Steatosis and steatohepatitis: complex disorders. Int J Mol Sci. 2014 Jun 3;15(6):9924-44

  4. Lavrik IN. 2014. Systems biology of death receptor networks: live and let die. Cell Death Dis. 5:e1259

  5. Lavrik IN, Zhivotovsky B. 2014. Systems biology: a way to make complex problems more understandable. Cell Death Dis. 5:e1259


  1. Schleich K, Lavrik IN. 2013. Mathematical modeling of apoptosis. Cell Commun Signaling 11:44.

  2. Schleich K, Krammer PH, Lavrik IN. 2013. The chains of death: A new view on caspase-8 activation at the DISC. Cell Cycle 12:193-194.

  3. Warnken U, Schleich K, Schnölzer M, Lavrik IN. 2013. Quantification of High-Molecular Weight Protein Platforms by AQUA Mass Spectrometry as Exemplified for the CD95 Death-Inducing Signaling Complex (DISC). Cells 2: 476-495.

  4. Schleich K, Lavrik, IN. Systems Biology of Death Receptor-Induced Apoptosis. In: ‚Systems Biology of apoptosis’. Publ. Springer. p.33-57. 2013.

  5. Rickert D, Fricker N, Lavrik IN, Theis FJ. Systematic Complexity Reduction of Signaling Models and Application to a CD95 Signaling Model for Apoptosis. In: ‚Systems Biology of apoptosis’. Publ. Springer. p 57-84. 2013

  6. Fricker N, Lavrik IN. Modeling Single Cells in Systems Biology. In: ‚Systems Biology of apoptosis’. Publ. Springer. p.145-162. 2013.

  7. Dieterle AM, Böhler P, Keppeler H, Alers S, Berleth N, Drießen S, Hieke N, Pietkiewicz S, Löffler AS, Peter C, Gray A, Leslie NR, Shinohara H, Kurosaki T, Engelke M, Wienands J, Bonin M, Wesselborg S, Stork B. 2013 PDK1 controls upstream PI3K expression and PIP3 generation. Oncogene. 2013 Jul 29. doi: 0.1038/onc.2013.266

  8. Pietkiewicz S, Sohn D, Piekorz RP, Grether-Beck S, Budach W, Sabapathy K, Jänicke RU. 2013. Oppositional regulation of Noxa by JNK1 and JNK2 during apoptosis induced by proteasomal inhibitors. PLoS One. 2013 Apr 11;8(4):e61438. doi: 10.1371/journal.pone.0061438.

  9.  Lavrik IN, editor, book 'Systems biology of apoptosis'. Publ. Springer. 2013.

  10. Öztürk S, Schleich K, Lavrik IN. CASP8 (Caspase 8, Apoptosis-Related Cysteine Peptidase). Atlas Genet Cytogenet Oncol Haematol. November 2013
  1. Schleich K, Warnken U, Fricker N, Oztürk S, Richter P, Kammerer K, Schnölzer M, Krammer PH, Lavrik IN. 2012. Stoichiometry of the CD95 Death-Inducing Signaling Complex: Experimental and Modeling Evidence for a Death Effector Domain Chain Model. Mol Cell. 47:306-319.

  2. Oztürk S, Schleich K, Lavrik IN. 2012. Cellular FLICE-like inhibitory proteins (c-FLIPs): fine-tuners of life and death decisions. Exp Cell Res 318:1324-1331.

  3. Lavrik IN, Krammer PH. 2012. Regulation of CD95/Fas signaling at the DISC. Cell Death Differ.1:36-41.



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